Amnestic mild cognitive impairment in Parkinson's disease: A brain perfusion SPECT study
Identifieur interne : 002454 ( Main/Exploration ); précédent : 002453; suivant : 002455Amnestic mild cognitive impairment in Parkinson's disease: A brain perfusion SPECT study
Auteurs : Flavio Nobili [Italie] ; Giovanni Abbruzzese [Italie] ; Silvia Morbelli [Italie] ; Roberta Marchese [Italie] ; Nicola Girtler [Italie] ; Barbara Dessi [Italie] ; Andrea Brugnolo [Italie] ; Cinzia Canepa [Italie] ; Giorgos Chr. Drosos [Italie] ; Gianmario Sambuceti [Italie] ; Guido Rodriguez [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-02-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Amnesia (diagnosis), Amnesia (epidemiology), Amnesia (physiopathology), Brain (blood supply), Brain (physiopathology), Cerebrovascular Circulation (physiology), Cognition Disorders (diagnosis), Cognition Disorders (epidemiology), Cognition Disorders (physiopathology), Cognitive disorder, Encephalon, Female, Humans, Male, Middle Aged, Nervous system diseases, Neuropsychological Tests, Parkinson Disease (epidemiology), Parkinson Disease (physiopathology), Parkinson disease, Parkinson's disease, Photon, Severity of Illness Index, Single photon emission tomography, Tomography, Emission-Computed, Single-Photon, amnestic mild cognitive impairment, brain SPECT, SPM, mild cognitive impairment.
- MESH :
- blood supply : Brain.
- diagnosis : Amnesia, Cognition Disorders.
- epidemiology : Amnesia, Cognition Disorders, Parkinson Disease.
- physiology : Cerebrovascular Circulation.
- physiopathology : Amnesia, Brain, Cognition Disorders, Parkinson Disease.
- Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Severity of Illness Index, Tomography, Emission-Computed, Single-Photon.
Abstract
The purpose of this study was to investigate cortical dysfunction in Parkinson's disease (PD) patients with amnestic deficit (PD‐MCI). Perfusion single photon emission computed tomography was performed in 15 PD‐MCI patients and compared (statistical parametric mapping [SPM2]) with three groups, i.e., healthy subjects (CTR), cognitively intact PD patients (PD), and common amnestic MCI patients (aMCI). Age, depression, and UPDRS‐III scores were considered as confounding variables. PD‐MCI group (P < 0.05, false discovery rate–corrected for multiple comparisons) showed relative hypoperfusion in bilateral posterior parietal lobe and in right occipital lobe in comparison to CTR. As compared to aMCI, MCI‐PD demonstrated hypoperfusion in bilateral posterior parietal and occipital areas, mainly right cuneus and angular gyrus, and left precuneus and middle occipital gyrus. With a less conservative threshold (uncorrected P < 0.01), MCI‐PD showed hypoperfusion in a left parietal region, mainly including precuneus and inferior parietal lobule, and in a right temporal‐parietal‐occipital region, including middle occipital and superior temporal gyri, and cuneus‐precuneus, as compared to PD. aMCI versus PD‐MCI showed hypoperfusion in bilateral medial temporal lobe, anterior cingulate, and left orbitofrontal cortex. PD‐MCI patients with amnestic deficit showed cortical dysfunction in bilateral posterior parietal and occipital lobes, a pattern that can be especially recognized versus both controls and common aMCI patients, and to a lesser extent versus cognitively intact PD. The relevance of this pattern in predicting dementia should be evaluated in longitudinal studies. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.22381
Affiliations:
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Martino University Hospital, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Girtler, Nicola" sort="Girtler, Nicola" uniqKey="Girtler N" first="Nicola" last="Girtler">Nicola Girtler</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Clinical Neurophysiology (DISEM, DipTeC), University of Genoa, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Dessi, Barbara" sort="Dessi, Barbara" uniqKey="Dessi B" first="Barbara" last="Dessi">Barbara Dessi</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Clinical Neurophysiology (DISEM, DipTeC), University of Genoa, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Brugnolo, Andrea" sort="Brugnolo, Andrea" uniqKey="Brugnolo A" first="Andrea" last="Brugnolo">Andrea Brugnolo</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Clinical Neurophysiology (DISEM, DipTeC), University of Genoa, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Canepa, Cinzia" sort="Canepa, Cinzia" uniqKey="Canepa C" first="Cinzia" last="Canepa">Cinzia Canepa</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Section of Neurology, Department of Neuroscience, Ophthalmology and Genetics, S. Martino University Hospital, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Drosos, Giorgos Chr" sort="Drosos, Giorgos Chr" uniqKey="Drosos G" first="Giorgos Chr." last="Drosos">Giorgos Chr. Drosos</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Clinical Neurophysiology (DISEM, DipTeC), University of Genoa, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Sambuceti, Gianmario" sort="Sambuceti, Gianmario" uniqKey="Sambuceti G" first="Gianmario" last="Sambuceti">Gianmario Sambuceti</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Nuclear Medicine (DIMI), S. Martino University Hospital, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author><author><name sortKey="Rodriguez, Guido" sort="Rodriguez, Guido" uniqKey="Rodriguez G" first="Guido" last="Rodriguez">Guido Rodriguez</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Clinical Neurophysiology (DISEM, DipTeC), University of Genoa, Genoa</wicri:regionArea><wicri:noRegion>Genoa</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-02-15">2009-02-15</date><biblScope unit="vol">24</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="414">414</biblScope><biblScope unit="page" to="421">421</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">8FA3710E7F523201F4933EE2C81D90BA25CD5E52</idno><idno type="DOI">10.1002/mds.22381</idno><idno type="ArticleID">MDS22381</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Amnesia (diagnosis)</term><term>Amnesia (epidemiology)</term><term>Amnesia (physiopathology)</term><term>Brain (blood supply)</term><term>Brain (physiopathology)</term><term>Cerebrovascular Circulation (physiology)</term><term>Cognition Disorders (diagnosis)</term><term>Cognition Disorders (epidemiology)</term><term>Cognition Disorders (physiopathology)</term><term>Cognitive disorder</term><term>Encephalon</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Neuropsychological Tests</term><term>Parkinson Disease (epidemiology)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Photon</term><term>Severity of Illness Index</term><term>Single photon emission tomography</term><term>Tomography, Emission-Computed, Single-Photon</term><term>amnestic mild cognitive impairment</term><term>brain SPECT, SPM</term><term>mild cognitive impairment</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Amnesia</term><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Amnesia</term><term>Cognition Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cerebrovascular Circulation</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Amnesia</term><term>Brain</term><term>Cognition Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Severity of Illness Index</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Déficit cognitif léger</term><term>Encéphale</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Photon</term><term>Tomoscintigraphie émission monophotonique</term><term>Trouble cognitif</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The purpose of this study was to investigate cortical dysfunction in Parkinson's disease (PD) patients with amnestic deficit (PD‐MCI). Perfusion single photon emission computed tomography was performed in 15 PD‐MCI patients and compared (statistical parametric mapping [SPM2]) with three groups, i.e., healthy subjects (CTR), cognitively intact PD patients (PD), and common amnestic MCI patients (aMCI). Age, depression, and UPDRS‐III scores were considered as confounding variables. PD‐MCI group (P < 0.05, false discovery rate–corrected for multiple comparisons) showed relative hypoperfusion in bilateral posterior parietal lobe and in right occipital lobe in comparison to CTR. As compared to aMCI, MCI‐PD demonstrated hypoperfusion in bilateral posterior parietal and occipital areas, mainly right cuneus and angular gyrus, and left precuneus and middle occipital gyrus. With a less conservative threshold (uncorrected P < 0.01), MCI‐PD showed hypoperfusion in a left parietal region, mainly including precuneus and inferior parietal lobule, and in a right temporal‐parietal‐occipital region, including middle occipital and superior temporal gyri, and cuneus‐precuneus, as compared to PD. aMCI versus PD‐MCI showed hypoperfusion in bilateral medial temporal lobe, anterior cingulate, and left orbitofrontal cortex. PD‐MCI patients with amnestic deficit showed cortical dysfunction in bilateral posterior parietal and occipital lobes, a pattern that can be especially recognized versus both controls and common aMCI patients, and to a lesser extent versus cognitively intact PD. The relevance of this pattern in predicting dementia should be evaluated in longitudinal studies. © 2008 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Nobili, Flavio" sort="Nobili, Flavio" uniqKey="Nobili F" first="Flavio" last="Nobili">Flavio Nobili</name></noRegion><name sortKey="Abbruzzese, Giovanni" sort="Abbruzzese, Giovanni" uniqKey="Abbruzzese G" first="Giovanni" last="Abbruzzese">Giovanni Abbruzzese</name><name sortKey="Brugnolo, Andrea" sort="Brugnolo, Andrea" uniqKey="Brugnolo A" first="Andrea" last="Brugnolo">Andrea Brugnolo</name><name sortKey="Canepa, Cinzia" sort="Canepa, Cinzia" uniqKey="Canepa C" first="Cinzia" last="Canepa">Cinzia Canepa</name><name sortKey="Dessi, Barbara" sort="Dessi, Barbara" uniqKey="Dessi B" first="Barbara" last="Dessi">Barbara Dessi</name><name sortKey="Drosos, Giorgos Chr" sort="Drosos, Giorgos Chr" uniqKey="Drosos G" first="Giorgos Chr." last="Drosos">Giorgos Chr. Drosos</name><name sortKey="Girtler, Nicola" sort="Girtler, Nicola" uniqKey="Girtler N" first="Nicola" last="Girtler">Nicola Girtler</name><name sortKey="Marchese, Roberta" sort="Marchese, Roberta" uniqKey="Marchese R" first="Roberta" last="Marchese">Roberta Marchese</name><name sortKey="Morbelli, Silvia" sort="Morbelli, Silvia" uniqKey="Morbelli S" first="Silvia" last="Morbelli">Silvia Morbelli</name><name sortKey="Rodriguez, Guido" sort="Rodriguez, Guido" uniqKey="Rodriguez G" first="Guido" last="Rodriguez">Guido Rodriguez</name><name sortKey="Sambuceti, Gianmario" sort="Sambuceti, Gianmario" uniqKey="Sambuceti G" first="Gianmario" last="Sambuceti">Gianmario Sambuceti</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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